Brown University

Fetal Medicine @ Brown

The Warren Alpert Medical School of Brown University

BIOL 6505 - Introduction to Fetal Medicine


There is no printed course pack or syllabus for this course. The syllabus itself is available in pdf format, and the list of references recommended for the various topics is below - you can go to the Brown University Library e-resources page to access the articles. Titles in red represent the core supportive articles - the others offer additional background information.

In addition, the books below may offer yet more references about this relatively new multidisciplinary specialty. For articles written by our own faculty on all topics fetal, click here.

ARTICLES (titles in red are considered core references)

  • Adzick NS et al. A Randomized Trial of Prenatal versus Postnatal Repair
    of Myelomeningocele. N Engl J Med February 2011.
  • Luks FI, Carr SR, Feit LR, Rubin LP. Experience with multidisciplinary antenatal diagnosis and management model in fetal medicine. J Mat Fet Neonat Med 14:1-5, 2003.
  • Lyerly AD, Gates EA, Cefalo RC, Surgarman J. Toward the ethical evaluation and use of maternal-fetal surgery. Obstet Gynecol 98:689-697, 2001.
  • Chervenak FA, McCullough LB. A comprehensive ethical framework for fetal research and its application to fetal surgery for spina bifida. Am J Obstet Gynecol 187:10-14, 2002.
  • Prince VE. The HOX paradox: More complex(es) than imagined. Dev Biol 249:1-15, 2002.
  • Niehrs C. A tale of tails. Nature 424:375-376, 2003.
  • Hubbard AM, Simon EM. Fetal imaging. MRI Clin N Am 10:380-408, 2002.
  • Marshall AC, van der Velde ME, Tworetzky W, Gomez CA, Wilkins-Haug L, Benson CB, Jennings RW, Lock JE. Creation of an atrial septal defect in utero for fetuses with hypoplastic left heart syndrome and intact or highly restrictive atrium septum. Circulation 110:253-258, 2004.
  • Tworetzky W, Wilkins-Haug L, Jennings RW, van der Velde ME, Marshall AC, Marx GR, Colan SD, Benson CB, Lock JE, Perry SB. Balloon dilatation of severe aortic stenosis in the fetus. Circulation 110:2125-2131, 2004.
  • Van den Veyver IB, Roa BB. Applied molecular genetic techniques for prenatal diagnosis. Curr Opin Obstet Gynecol 10:97-103, 1998.
  • Feit LR. Fetal cardiac arrhythmias: Diagnosis and management. Med Health RI 84:161-164, 2001.
  • Bannister CM. The case for and against intrauterine surgery for myelomeningoceles. Eur J Obstet Gynecol Reprod Biol 92:109-113, 2000.
  • Coplen DE. Prenatal intervention for hydronephrosis. J Urol 157:2270-2277, 1997.
  • Kurkchubasche AG. The fetus with an abdominal wall defect. Med Health RI 84:159-161, 2001.
  • Rubin LP, Hansen K. Testing for hematologic disorders and complications. Clin Lab Med 23:317-343, 2003.
  • Hirose S, Harrison MR. The ex utero intrapartum treatment (EXIT). Sem Neonatol 8:207-214, 2003.
  • Luks FI. Requirements for fetal surgery: the diaphragmatic hernia model. Eur J Obstet Gynecol Reprod Biol 92:115-118, 2000.
  • Flake AW. Surgery in the human fetus: The future. J Physiol 547:45-51, 2003.
  • Carr SR, Plevyak MP. Contemporary evaluation and management of twin-twin transfusion syndrome. Med Health RI 84:165-168, 2001.
  • Richard P. Harvey, RP and Rosenthal, N, Editors of "Heart Development." Academic Press, San Diego, 1999.
  • Gilbert, SF, Editor of "Developmental Biology", 5th edition. Sinauer Associates, Sunderland, MA, 1997.
  • Holland PW: Beyond the Hox: how widespread is homeobox gene clustering? J Anat. 2001, (Pt 1-2):13-23.
  • Martinez P, Amemiya CT: Genomics of the HOX gene cluster. Comp Biochem Physiol B Biochem Mol Biol. 2002, 133(4):571-80.
  • Epstein JA, Buck CA: Transcriptional regulation of cardiac development: implications for congenital heart disease and DiGeorge syndrome. Pediatr Res. 2000, 48(6):717-24.
  • Mariani FV, Martin GR. Deciphering skeletal patterning: Clues from the limb. Nature 2003, 423(6937):319-25.
  • Niehrs C. Developmental biology: A tale of tails. Nature 2003, 424(6947):375-6.
  • Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature. 2000, 407(6801):221-6.
  • McLorie G., Walid F, Khoury, A., Geary, D., Ryan, G. Outcome Analysis of Vesicoamniotic Shunting in a Comprehensive Population. American Urological Association 2001, 166:1036-1040.
  • Herndon CDA, Ferrer F., Freedman A, McKenna P. Consensus on the Prenatal Management of Antenatally Detected Urological Abnormalities. American Urological Assocation 2000, 164:1052-1056.
  • Harrison M, Keller R, Hagwood S. A Randomized Trial of Fetal Endoscopic Tracheal Occlusion for Severe Fetal Congenital Diaphragmatic Hernia. New England Journal of Medicine 2003 (349)1916-1924.
  • Carpenter N. Molecular Cytogenetics. Seminars in Pediatric Neurology September 2001 (8)135-146.
  • Coalson, J. Pathology of New Bronchopulmonary Dysplasia. Seminar in Neonatology 2003. (8) 73-81.
  • Thebaud B, Barlier-Mur A, Chailley-Heu B. Restoring Effects of Vitamin A on Surfactant Synthesis in Nitrofen-induced Congenital Diaphragmatic Hernia in Rats. Am J Respir Crit Care Med 2001 (164) 1083-1089.
  • Wenstrom K, Fetal Surgery for Congenital Diaphragmatic Hernia. New England Journal of Medicine 2003 (349)1887-1888.
  • Rubin L. Alpha-thalassemia Major: Antenatal Diagnosis and Management. Medicine and Health Rhode Island 2001 (84) 152-155.
  • Siddiq F, Caldamone A. Fetal Obstructive Uropathy: Diagnosis and Management. Medicine and Health Rhode Island 2001 (84) 155-158.



  • Harrison MR, Evans MI, Adzick NS, Holzgreve W. Mark I. Evans, N. Scott Adzick, Wolfgang Holzgreve. The Unborn Patient: The art and science of fetal therapy. 3rd Edition, W.B. Saunders 2001
  • Bianchi DW, Crombleholme TM, D'Alton ME. Fetology: Diagnosis and Management of the Fetal Patient. McGraw-Hill, New York 2000










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