Brown University

Fetal Medicine @ Brown

The Warren Alpert Medical School of Brown University

Twin to Twin Transfusion Syndrome
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Research into Twin-to-twin Transfusion Syndrome

Face (above) and hand of a 20-week-old fetus, as seen through the lens of a fetal endoscope during surgery for Twin-to-twin Transfusion Syndrome

Our center is actively involved in medical research, including research into the causes and the treatment of twin-to-twin transfusion syndrome. Research interests include the fine-tuning of actual surgical techniques and examining the placental vessels after delivery to better understand the causes of TTTS. Below is a list of recent publications on the topic.

Carr SR, Plevyak MP.
Contemporary evaluation and management of twin-twin transfusion syndrome.
Med Health RI 2001;84:165-168.

Luks FI, Carr SR, Ponte B, Rogg JM, Tracy TF, Jr.
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome.
Am J Obstet Gynecol 185:216-219, 2001.

Fig. 1. A 29-week diamniotic–monochorionic placenta before (left) and after (right) vascular injection. Color code: yellow, artery twin A; blue, vein twin A; red, artery twin B; green, vein twin B. Arteries are seen crossing over veins. Inset shows a deep artery-to-vein (AV) anastomosis between yellow artery of twin A and green vein of twin B (direction: A3B). De Paepe ME, et al.
Pediatr Dev Pathol 5, 37–44, 2002 © 2002 Society for Pediatric Pathology

De Paepe ME, Burke S, Luks FI, Pinar H, Singer DB.
Demonstration of placental vascular anatomy in monochorionic twin gestations.
Pediatr Dev Pathol 5:37-44, 2002.

De Paepe ME, Stopa E, Huang C, Hansen K, Luks FI.

Renal tubular apoptosis in twin-to-twin transfusion syndrome.
Pediatr Dev Pathol 6:215-225, 2003.

Luks FI, Carr SR, Feit LR, Rubin LP.
Experience with a Multidiscipinary Antenatal Diagnosis And Management model in fetal medicine.
J Mat Fet Neonat Med 14:333-337, 2003.

Bussey JG, III, Luks FI, Carr SR, Plevyak M, Tracy TF, Jr.

Minimal access fetal surgery for twin-to-twin transfusion syndrome (TTTS).
Surg Endosc 18:83-86, 2004.

De Paepe ME, Friedman R, Poch M, Hansen K, Carr SR, Luks FI.
Placental findings after laser ablation of communicating vessels in twin-to-twin transfusion syndrome (TTTS).
Pediatr Dev Pathol 7:159-165, 2004.

Luks FI, Carr SR, Plevyak M, Craigo SD, Athannasiou A, Ralston SJ, Tracy, TF, Jr.

Limited prognostic value of a staging system for twin-to-twin transfusion syndrome.
Fetal Diagn Ther 19:301-304, 2004.

Carr SR, Luks FI, Tracy TF, Jr., Plevyak M.

Antenatal Necrotic Injury in Severe Twin-to-Twin Transfusion Syndrome. A Case and Review.
Fetal Diagn Ther 19:370-372, 2004.

Poch M, Luks FI, Carr SR, De Paepe ME.

Intratwin arteriovenous fistula of the placenta in a case of twin-to-twin transfusion syndrome.
Am J Perinatol 22:3-6, 2005.

Luks FI, Carr SR, De Paepe ME, Tracy TF, Jr.

What - and why - the pediatric surgeon should know about twin-to-twin transfusion syndrome.
J Pediatr Surg 40:1063-1069, 2005.


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