Faculty
Stephen Salloway
, MD, MS
Professor of Neurology:
BIO MED NEUROLOGY
Phone: +1 401 455 6403
Stephen_Salloway@Brown.EDU
Read Stephen Salloway's full Faculty Research Profile.
Research Interests
My research focuses on the following areas: clinical trials for the prevention and treatment of Alzheimer's disease, mild cognitive impairment, and vascular dementia; studies of genetic and sporadic forms of microvascular brain disease; studies of executive function and frontal behaviors; and the development of imaging biomarkers to study conversion to dementia.
Biography
Stephen Salloway, MD, MS, is Director of Neurology and the Memory and Aging Program at Butler Hospital in Providence, Rhode Island, and Professor of Clinical Neurosciences and Psychiatry at Brown Medical School. He is the Director of the Brown Combined Residency in Neurology and Psychiatry and Codirector of the National Institute on Aging-sponsored Brown Dementia Research Fellowship Program. He received his MD from Stanford Medical School and completed residencies in neurology and psychiatry at Yale University.
Dr. Salloway has published more than 185 scientific articles, book chapters, and abstracts and has edited 3 books. His research focuses on the following areas: clinical trials for the prevention and treatment of Alzheimer's disease, mild cognitive impairment, and vascular dementia; studies of genetic and sporadic forms of microvascular brain disease; studies of executive function and frontal behaviors; and the development of imaging biomarkers to study conversion to dementia. Dr. Salloway has received numerous grants for his research from the National Institutes of Health and from private foundations. He published the first controlled clinical trials of cholinesterase inhibitors for the treatment of mild cognitive impairment and vascular dementia. Under his direction, the Butler Memory and Aging Program has become a nationally recognized clinical research center that tests new disease-modifying treatments for Alzheimer's disease, including amyloid vaccines, gamma secretase inhibitors and modulators, antifibrillization agents, and RAGE inhibitors. His program has also become a key research center in the United States for the study of CADASIL, a genetic disorder that causes stroke and vascular dementia.
Dr. Salloway is a past president of the American Neuropsychiatric Association, a fellow of the American Academy of Neurology, and a member of the American Neurological Association. He is a scientific reviewer for the National Institutes of Health and for more than 30 journals, universities, and research foundations. Dr. Salloway lectures widely on dementia and he is a leading proponent of the early diagnosis and treatment of Alzheimer's disease.
Teaching
HOSPITAL AND UNIVERSITY TEACHING ROLES
1980-1981 University of California Berkeley
Teaching Assistant for the course: Human Growth and Development for medical and graduate students.
1983-1985 Stanford Medical School
Coordinator of the psychiatry and behavioral science curriculum in the Primary Care Program
Instructor for the course: Introduction to Clinical Medicine
1989-1991 Yale University
Director of the course: Behavioral Neurology - for medical students Seminar
Director: Neuroradiology/Clinical Correlations for the psychiatry housestaff and attending staff at Yale-New Haven Hospital
Co-director of the bi-weekly Movement Disorder seminar at Yale University
Instructor for the neurology section in The Introduction to Clinical Medicine Course for Medical Students
1990-1995 Yale University
Co-director of the course: Comprehensive Review of Neurology
Offered 2 times per year
1991-present Brown University
Undergraduate Education
Director of an Independent Study Course in neurobehavioral research for undergraduates majoring in neuroscience and biology (B195/196) (1-3 students per semester, includes honors thesis for eligible seniors).
Lisa Israeli, Neuroscience, fall and spring semesters 1994-5 and 1995-6.
Project: Development of a brain imaging rating scale. Co-author of one peer reviewed paper and one abstract.
Kathy Chang, Neuroscience, spring 1994-95, fall 1995-96.
Project: Clinical profiles of adults presenting with attentional disturbance. Honorable mention for the ANPA Young Investigator Award for abstract #12 at the American Neuropsychiatric Association Annual Meeting 1995.
Mary Lynn Mercado, Biology, spring 1994-95, fall and spring semesters 1995-96. Senior honors thesis: Subcortical vascular disease and late-life depression
Joseph Hong, Neuroscience, spring semester 1995-96, University Teaching and Research Assistant (UTRA) summer 1996, fall, spring 1996-97 Projects: I. Effect of pemoline on cognitive performance, II. Honors thesis. MRI and small artery changes in CADASIL and Binswanger's disease. Author of two peer-reviewed papers and Presentation at two national meetings
Jorge Intal, Neuroscience, summer 1996, fall, spring 1996-97
Project: Cerebral microvascular disease in aging: I. A comparison of FLAIR and PD MRI sequences and II. MRI-autopsy correlation of signal hyperintensities. Presented at the Society for Neuroscience 27th Annual Meeting, New Orleans (abstract #21).
Maureen Cruz, Biology, fall 1997
Project: Cerebral perfusion abnormalities in normal pressure hydrocephalus.
Mary Pan, Neuroscience, fall and spring 1998-9
Project: Neuropsychiatric symptoms in vascular dementia
Susan Rymer, Anthropology, fall and spring 1999-2000
Project: Awareness of cognitive deficit in Alzheimer's disease and caregiver burden
Tamar Gur, Biology Honors Thesis second reader, 1999-2000
Project: ApoE4 and agrin staining of microvascular integrity in Alzheimer's disease (co-mentor with Dr. Stopa)
Ellen Kotwas, spring 1999-2000, summer and fall 2000-2001
UTRA Fellow, Psychology Honors Thesis
Project: Affective and semantic priming in Alzheimer's disease
Awarded the Muriel Fain Sher Premium in Psychology by the Department of Psychology for her honors research (co-mentor with Dr. Heindel)
Audrey Kwak, 2001-2, Psychology Honors Thesis
Project: Predictors of functional impairment in Alzheimer's disease
Leah Belsky, 2001-2 Biology
Project: When familial FTD is suspected: Ethical and clinical issues in genetic research
Sophie Desbiens, Summer 2002 Brain Science UTRA Fellow
Project: Development of an assay for notch-3 mutations
Suzanne Drodge, Summer 2002 MRI Research Facility UTRA Fellow
Project: Diffusion tensor imaging in CADASIL
Stan Pelosi, Summer 2002 PLME summer research assistantship
Project: Working memory in Alzheimer's disease (co-mentor with Dr. Malloy)
Jonathan Greer, 2003 PLME summer research assistantship
Project: A PCR-SSCP reliant assay for notch-3 mutations in CADASIL patients
Irmak Turan, Barrington High School Senior Project (awarded honors)
Project: Is Down's syndrome a good genetic model for studying Alzheimer's disease?
Ryan Li, 2003-4 Neuroscience honors thesis
Project: MRI correlates of ambulation and motor functioning in Alzheimer's disease.
Thea Brennan-Krohn, 2004 Summer Training in Aging Research Topics Mental Health- NIMH Award- Diffusion tensor imaging and working memory in SIVD. 2005 Summer Training in Aging Research Topics Mental Health NIMH Award- Molecular analysis of notch and notch ligand expression in vascular dementias
Christopher Song, 2004 Summer Training in Aging Research topics Mental Health- NIMH Award
Project: Development of an assay for notch3 mutations
Sharon Song, 2007 Biology concentrator honors thesis (co-mentor with Stephen Correia, PhD)
Project: MOCA is more sensitive than MMSE in MCI because of executive dysfunction..
Brown Medical Student Education
Director of the second semester, first year course. The Human Brain and Behavior (Biomed 370)
Co-leader of a small group and lecturer in the Neurologic Pathophysiology Course for second year students (Neurosciences 262)
Director, Neuropsychiatry and Behavioral Neurology Elective (Biomed 515)
Extended Medical Student Research Elective
Ximena Morales, 1994-95, Medical School Columbia, South America, six month neurobehavioral research elective in geriatric depression
Shirine Nassery, PLME summer research assistantship 2001
Relationship of subcortical microvascular changes in Alzheimer's disease to ApoE genotype and systolic hypertension
Risha Kopel, summer research project 2001
Use of diffusion tensor MRI to differentiate normal pressure hydrocephalus from Alzheimer's disease
Tyler Berzin, 2001-2, Brown Faculty Scholars Award recipient
Microvascular changes in Alzheimer's disease (co-mentor with Dr. Stopa)
Ari Blitz, 2000-1, Brown faculty Scholars recipient
Alterations in frontal-subcortical circuits in OCD
Ainsley MacLean, 2002 PLME summer research assistantship
Phenotypic variation in a large family with CADASIL, Recipient of an Alzheimer's Association Travel Award to present her work at the 8th World Alzheimer's Disease Congress in Stockholm, 7/2002
Colleen Craig 2005 3rd year medical student 6 month longitudinal neurology elective
Michael Joseph, Summer 2005, Clinical Neuroscience Mental Health Research Training-R25 MH 60477-05 Relationship of hippocampal and whole brain volume to cognitive impairment in CADASIL
James Enos, 2008 Summer Training in Aging Research Topics Mental Health NIMH Award, Normal pressure hydrocephalus: clinical-pathological correlations. primary mentor with Dr. delaMonte.
Brown Post-graduate Medical Education
Director of the American Board of Psychiatry and Neurology/ACGME-Approved 855-43-44-005 Brown University Combined Residency Training Program in Neurology and Psychiatry.
NIA ZAG1 FAS-5 J1 Institutional National Research Service Award
Dementia Research Fellowship T-32 (Paul Malloy, PI) 2003-2008, co-PI with Richard Besdine
Director of the Neuropsychiatry/Behavioral Neurology Fellowship
Director of the Neuropsychiatry Track in the Psychiatry Residency
Neurology Ward and Consultation Service Attending - Rhode Island Hospital
Neurology Consultation Service Attending - Butler Hospital
Behavioral Neurology Outpatient Elective Rotation Attending
Mentor, Brown Psychiatry Residency Research Track
Lecturer in the Brown University Neuropsychology Training Seminar
Lecturer in the weekly neurology resident seminar series
Lecturer in the Geriatric Psychiatry and Geriatric Medicine fellowship programs
Lecturer on Geriatric research in the Brown University NIH T-32 Young Investigator
Training Seminar
Director of the Brown University Neuropsychiatry/Behavioral/Neurology Grand Rounds Series- Butler Hospital
Co-director of Brown University Neuroradiology Rounds – Butler Hospital.
Brown Medical School Extended Resident Electives
Cleve Shirey, M.D. Senior Psychiatry Resident, 1993-4, Year-long one-half day weekly neuropsychiatry outpatient continuity clinic
Suda Bakshi, M.D. Triple Board Resident in Pediatrics, Child Psychiatry and Adult Psychiatry, 1994-5, Nine month one-half day weekly neuropsychiatry outpatient clinic
Jeffrey Daly, M.D.Senior Psychiatry Resident, 1994-5, Twelve month, part-time elective in neuropsychiatric research. Published two peer-reviewed articles and one book chapter and was selected for the American Psychiatric Association Burroughs-Wellcome Award.
Neeta Jaine, M.D. Senior Psychiatry Resident, 1995-6, Four month weekly neuropsychiatry outpatient continuity clinic
Ron Neeper, M.D., Ph.D., Triple Board Resident in Pediatrics, Child Psychiatry and Adult Psychiatry and Pediatric Neurology Resident 1994-6, Two year neuropsychiatry continuity clinic two half-days/week
Gary Epstein-Lubow, M.D., Senior Psychiatry Resident, Four month weekly neuropsychiatry outpatient elective 2001, Project-Neuropsychiatric aspects of NPH
Combined Residents in Neurology and Psychiatry
Curt LaFrance, M.D., 1995-2001
Current position: NIMH Research Fellow at Rhode Island Hospital. Recipient of a NINDS Career Development Award 2003-8.
Rochelle Woods, M.D., 1999-present
Research project: Validating a scale for measuring outcome from intracerebral hemorrhage.
Neuropsychiatry Fellows
John Campbell, M.D., 1992-1993
Published two peer-reviewed papers and made two Presentations at national meetings during the fellowship. Current Position-Director of Neuropsychiatry, Henry Ford Hospital, Detroit, MI
Colin Harrington, M.D., 1996-97
Current position-Director of Consultation-Liaison Psychiatry, Rhode Island Hospital. Dr. Harrington received the 2003 Senior Citation Award for best faculty mentorship from the 2003 Brown Medical School graduating seniors.
T-32 Post-Doctoral Research Fellows
Stephen Correia, Ph.D., 2003-2005
Working memory and frontal white matter integrity in mild cognitive impairment (mentor)
Gary Lubow, M.D., 2003-2005
Treatment of depression in dementia caregivers (co-mentor with Van Miller, Ph.D.)
Visiting Scholars
Paul O'Hara, M.D., 1998-2000, University of Western Australia
Research supervisor, Controlled treatment trials for vascular dementia
Neuropsychology Post-Doctoral Fellows
Deborah Cahn-Weiner, Ph.D., 1996-98
Research Supervisor, Cognitive performance and functional status in normal aging and dementia (co-mentor with Dr. Malloy)
Current position-staff psychologist Memorial Hospital of RI
Lauren Norton, Ph.D., 1998-2000
Research Supervisor, Behavioral symptoms and activities of daily living in dementia (co-mentor with Dr. Malloy)
Current position staff psychologist Massachusetts General Hospital
Patricia Boyle, Ph.D., 2000-2002
Research supervisor, NIA F-32 Executive function and activities of daily living in Alzheimer's disease (co-mentor with Dr. Malloy)
Current position Director of Neuropsychology BU Alzheimer's Center
Stephen Correia, Ph.D., 2002-2005
Research supervisor, NIA T-32 Dementia Research Fellow
Diffusion tensor imaging of frontal systems in mild cognitive impairment. (co-mentor with Dr. Malloy)
Ryan Garrity, Ph.D., 2000-2002
Research supervisor, A trial of estrogens for prevention of Alzheimer's disease (co-mentor with Dr. Malloy) Current position-staff psychologist
Heather Belanger, Ph.D., 2002-2003
Research supervisor, Diffusion tensor imaging and executive function in Alzheimer's disease (co-mentor with Dr. Malloy)
Kelly Wilder-Willis, Ph.D., 2002-2004
Research supervisor, Working memory in Alzheimer's disease (co-mentor with Dr. Malloy)
Laura Frakey, Ph.D., 2005-2007
Research supervisor, Treatment of apathy in Alzheimer's disease with modafinil (co-mentor with Dr. Malloy)