Division of Gastroenterology - Liver Research Center 















Suzanne de la Monte, M.D., M.P.H.

Associate Professor of Pathology and Medicine

Address:

Pierre Galletti Laboratories
55 Claverick Street, 4th Floor
Providence, RI 02903
phone: 401-444-7441
fax: 401-444-2939
E-mail: Suzanne_DeLaMonte_MD@Brown.edu

Clinical Interests:

Neuropathology and general pathology.

Research Interests:

I am interested in the molecular mechanisms of programmed cell death as well as the role of aspartyl (asparaginyl)-beta-hydroxylase (AAH) in cell motility and invasiveness of tumor cells as well as neuronal cells. In addition, our studies focus on growth factor signaling through IRS-1 and the role of this pathway in oncogenesis.

Expression of AAH in Pancreatic Cancer

Selected Publications:

de la Monte SM, Tamaki S, Cantarini MC, Ince N, Wiedmann M, Carter JJ, Lahouse SA, Califano S, Maeda T, Ueno T, D’Errico A, Trevisani F, Wands JR.  Aspartyl-(asparaginyl)-b-hydroxylase regulates hepatocellular carcinoma invasiveness.  J of Hepatology 2006: 44 (in press).

Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM.Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis. 2005 Dec;8(3):247-68.

de la Monte SM, Xu XJ, Wands JR. Ethanol inhibits insulin expression and actions in the developing brain. Cell Mol Life Sci. 2005 May;62(10):1131-45.

Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis. 2005 Feb;7(1):63-80.

de la Monte SM, Wands JR.Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis. 2005 Feb;7(1):45-61.

Maeda T, Taguchi K, Aishima S, Shimada M, Hintz D, Larusso N, Gores G, Tsuneyoshi M, Sugimachi K, Wands JR, de la Monte SM.Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma. Cancer Detect Prev. 2004;28(5):313-8.

 

 

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