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Molecular Biology, Cell Biology and BiochemistryBox G-L207, Providence, RI 02912 The Department of Molecular Biology, Cell Biology, and Biochemistry is the largest on-campus department in the Division of Biology and Medicine. We offer a wide range of undergraduate and graduate courses that form the core of modern experimental biology. Our faculty offer training in genetics, biochemistry, developmental biology, cellular biology, molecular biology, genomics, and proteomics. Departmental research employs state of the art optical tools such as electron and confocal scanning microscopy, physical techniques such as X-ray diffraction, and innovative techniques in molecular biology. The Department is devoted to cutting-edge research that addresses basic questions in biology, including the control of gene expression, cell fate determination, protein synthesis, the genetics of behavior, control of the cell cycle, signaling pathways within the cell, and the role of prions in cellular activity. A distinguished faculty, well-represented on editorial and professional boards and societies, directs undergraduate, graduate, and postdoctoral work in the Department. Courses - 2008-09
Faculty - Who We Are and What We DoWalter Atwood, PhD, Professor. Virus-receptor interactions; neuropathogenic viruses. Samuel Beale, PhD, Professor. Biosynthesis of pigments (chlorophyll, heme, bilin). Alexander Brodsky, PhD, Assistant Professor. Systems of biology of post-transcriptional regulation, steroid hormone control of cancer. Robbert Creton, PhD, Assistant Professor (Research). The molecular and celluar physiology of early embryonic development. Albert Dahlberg, MD, PhD, Professor. Ribosomes and ribosomal RNA structure and function. Alison DeLong, PhD, Associate Professor. Protein phosphorylation and signal transduction in Arabidopsis . William Fairbrother, PhD, Assistant Professor. Molecular Biology, Computational Biology, Cell Biology, RNA biology, and Gene Expression. Anne Fausto-Sterling, PhD, Professor. Using principles of development systems theory to understand the emergence of gendered and racialized bodies. Selected topics in the history of early 20th Century biology. Laboratory research examines the dynamics of gender in infant development. Richard Freiman, Assistant Professor. Chromatin and transcriptional control; regulation of tissue specific gene expression in the mouse reproductive system. Susan Gerbi, PhD, Professor. RNA-RNA interactions (rRNA, U3 snRNA, 7SL of SRP); chromosome structure and DNA replication; molecular evolution. Jody Hall, Teaching Associate & Manager, Undergraduate Laboratories. Stephen Helfand, PhD, Professor. Molecular genetics of aging and longevity. Peter Heywood, PhD, Professor. Literature surveys, particularly in the area of agricultural biotechnology, sustainable agriculture, and food production. Gerwald Jogl, PhD Assistant Professor. Protein crystallography, post-translational ribsome modification, autophagy, signal-transduction pathways. Mark Johnson, PhD, Assistant Professor. Molecular genetic analysis of plant reproductive development: Mechanisms of targeted pollen tube growth in Arabidopsis. Arthur Landy, PhD, Professor. Mechanism of site-specific recombination; protein-DNA interactions; structure of higher-order protein-DNA complexes. Jeffrey Laney, PhD, Assistant Professor. Role of proteolysis in the dynamics of gene expression. Michael McKeown, PhD, Professor. Behavioral genetics in Drosophila. Kenneth Miller, PhD, Professor. Cell structure; membrane structure and composition; electron microscopy. Kimberly Mowry, PhD, MPH, Professor. mRNA localization during oogenesis; Xenopus development. Rebecca Page, MD, Assistant Professor. Protein X-ray crystallography; neuronal scaffolding protein complexes; phosphatase/kinases critical for the immune system and cancer. Robert Reenan, PhD, Professor. Evolution of brain function and behavior. Our primary model system is Drosophila, the fruit fly, for its powerful traditional and molecular genetics. Our main question is: How do genomes encode and regulate proteins involved in rapid electrical and chemical signaling in the brain, normally and in disease? Arthur Salomon, PhD, Assistant Professor. Exploitation of emerging proteomic technologies to probe cellular signaling networks; development of bioinformatics tools to distill data generated in modern protemics experiments. John Sedivy, PhD, Professor, Chair. Aging of mammals, replicative cellular senescence, cell cycle control. Tricia Serio, PhD, Associate Professor. Prion propagation; translation termination. Jeffrey Singer, PhD, Assistant Professor. Ubiquitin mediated proteolysis, mammalian cell cycle, mouse knockouts. Marjorie Thompson, PhD, Associate Professor, Associate Dean of Biological Sciences (Undergraduate Education). Biological and medical illustration. Gary Wessel, PhD, Professor. Primordial germ cell development; Biology of multi-potent stem cells; Cell and molecular biology of fertizalization.. Kristi Wharton, PhD, Associate Professor. Role of growth factors and signal transduction in cell fate determination and differentiation during development; Drosophila developmental genetics. Mark Zervas, PhD, Assistant Professor. How dopamine neuron circuits develop, how and when the loss of dopamine neurons of a distinct genetic lineage affects brain function, mechanisms of specifying/maintaining dopamine neurons and cell-based therapies to ameliorate deficits in genetically altered mice with features of neurological disorders. Recent Student Projects
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